Anthony Davis and LeBron James starred as the Lakers topped the Rockets 110-100 for a commanding lead in the Western Conference semifinals.
Davis posted a double-double and James finished one assist shy of a triple-double to help the top-seeded Lakers take a 3-1 lead in the best-of-seven NBA playoff series.
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Davis put up 29 points and 12 rebounds in Game 4 at Walt Disney World Resort on Thursday, while James recorded 16 points, 15 rebounds and nine assists.
The Lakers led by as many as 23 points midway through the fourth quarter and looked on track for a blowout victory before the Rockets rallied.
Houston, which overcame a 3-1 deficit in the second round of the 2015 playoffs, put together an 18-2 run to close to 103-96 but the Lakers managed to hold on in the Orlando bubble.
Russell Westbrook led the Rockets with 25 points. All-Star teammate James Harden contributed 21 points.
Game 5 between the Lakers and Rockets will be Saturday.